David Sinclair Supplement Routine at a Glance:
- Routine: Sinclair takes 15 supplements daily, costing approx. $445 per month.
- Focus: Longevity, cellular repair, and aging reversal.
- Selection Method: Picks supplements based on his clinical studies, focusing on NAD+ boosting (a key molecule for cell energy and repair), protecting cells, and removing damaged ones.
- Philosophy: Sinclair sees aging as treatable, using supplements that restore cells, repair DNA, and mimic fasting to slow aging.
David Sinclair Complete Supplement Stack
David Sinclair is a Harvard geneticist and longevity researcher focused on reversing aging at the cellular level.
A pioneer in anti-aging science, he studies how NAD+ (key molecule for cells) can slow or even reverse aging. In his bestselling book, Lifespan: Why We Age—and Why We Don’t Have To, he explores ways to extend health and lifespan.
He hosts the podcast, Lifespan with David Sinclair and is a regular guest on: The Joe Rogan Experience, The Tim Ferriss Show, FoundMyFitness (Rhonda Patrick), The Kevin Rose Show, and The Huberman Lab.
Click below to see what he takes and why.
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Foundational
Supplements to help overall wellness and long-term well-being.
- Vitamin D3 → 4,000 IU daily
- Vitamin K2 → 240 mcg daily
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Brain
Supplements to improve memory, focus, clarity & neuroplasticity.
- Omega-3s (Fish Oil) → 3 g daily
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Longevity
Supplements to supercharge cell repair, energy & regeneration.
- Alpha Lipoic Acid → 400 mg daily
- Aspirin → 81 mg daily
- CoQ10 (Ubiquinol) → 150 mg daily
- Fisetin → 500 mg daily
- L-Taurine → 2 g daily
- Metformin → 900 mg daily
- NMN → 1 g daily
- Rapamycin → 6 mg occasionally (weekly)
- Resveratrol → 1 g daily
- Spermidine → 1.5 mg daily
- Statin (Prescription) → 1 capsule daily
- Trimethylglycine (TMG) → 750 mg daily